Protein Details: Potassium voltage-gated channel protein egl-36

Protein ID

ICDB_Pro_0146

Protein Name

Potassium voltage-gated channel protein egl-36

Gene Name

egl-36; R07A4.1

Organism

Caenorhabditis elegans

Length

558 amino acids

AlphaFoldDB

AF-G5EFC3-F1-model_v4.pdb

Function

Voltage-dependent potassium channel involved in the excitation of muscles operating egg-laying and defecation

Sequence

MLDACSFNRFDSNRSSARRFSRRGSDYFGDKGISMDERIVLNVGGVRHETYQATLKKIPATRLSRLTPSLANFDPLLNEYFFDRHPAVFAMILNYYRTGKLHYPTDVCGPLFEEELQYWGLDASDTEPCCWMQLLHAKDTQETLAVLDRMDADHEDDPQLREQDTMKKFGWEEDYFQGKRTRWMKLKPQMWSLFDEPYSSQAAKLIAGISVLFIFISIFSFCLKTHQSFRLPVLIGQNITMPGGVVQPSIERVSTEPLPIFGQIEMLCNIWFTLELIIRFVFCPSKIRFFKSPLNMIDLVATLSFYADAMMVRVVEDEPKDVVEFLSMIRIFRLFKLTQHHQGLQILIHTFRASAKELILLVFFLILGIVIFAALVYYAEKMEANPNNQFQSIPLGLWWAICTMTTVGYGDMTPHTSFGRLVGSLCAVMGVLTIALPVPVIVSNFAMFYSHNQARDKLPKRRRRVLPVEQIRLQARRHAAVLEPSASQGGLGGGQAIRRRNMPILIDQNCCDEENHNHKHREKSENSDEGTNSSSTTGVDTVVKLGPSETAITTTIIS

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Expressed in muscles for egg-laying; anal depressor and sphincter; and the four most anterior head muscles. Found in neurons including enteric motor neurons AVL and DVB and the sensory neuron PHB; the spermatheca; and the distal tip cells of the somatic gonad.

DOI ID

10.1126/science.282.5396.2012; 10.1016/s0896-6273(00)80355-4; 10.1016/s0896-6273(00)80356-6

RefSeq

NP_509795.1